Article

Metabolic Reprogramming via targeting ACOD1 promotes polarization and anti-tumor activity of human CAR-iMACs in solid tumors

2023-04-21

Abstract excerpt

The pro-inflammatory state of macrophages is crucial in conferring its role in combating tumor cells. That state is closely associated with metabolic reprogramming. Here we identified key metabolic genes regulating macrophage pro-inflammatory activation in a pooled metabolic gene knockout CRISPR screen. We found that KEAP1 a nd ACOD1 are strong regulators of the pro-inflammatory state, and therefore developed hu...

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Literature Corpus work: f10555c5-eba1-55df-b2ab-40942ad4444f
DOI: 10.1101/2023.04.20.537647

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Metabolic Reprogramming via targeting ACOD1 promotes polarization and anti-tumor activity of human CAR-iMACs in solid tumorsDOI 10.1101/2023.04.20.537647Read

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