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Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A

7 Jan 2014

Abstract excerpt

Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency. We now report that the expression of the folate transporters differs between macrophage subtypes and explains the higher accumulation of...

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PMID: 24399840
DOI: 10.1189/jlb.0613345

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