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Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly

9 Jul 2014

Abstract excerpt

Inflammasomes are macromolecular complexes that mediate inflammatory and cell death responses to pathogens and cellular stress signals. Dysregulated inflammasome activation is associated with autoinflammatory syndromes and several common diseases. During inflammasome assembly, oligomerized cytosolic pattern recognition receptors recruit procaspase-1 and procaspase-8 via the adaptor protein ASC. Inflammasome...

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PMID: 25006247
DOI: 10.1074/jbc.m114.553305

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Related research

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Research trail→

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Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome AssemblyPMID 25006247Read ↗

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The immunological function of familial Mediterranean fever disease protein PyrinSemantic proximity Read ↗

The PRY/SPRY domain of pyrin/TRIM20 interacts with β2-microglobulin to promote inflammasome formation.Semantic proximity Read ↗

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN RecognitionSemantic proximity Read ↗

Biochemical and structural aspects of the ATP‐binding domain in inflammasome‐forming human NLRP proteinsSemantic proximity Read ↗

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.Semantic proximity Read ↗

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