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NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

3 Aug 2020

Abstract excerpt

The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is an immunological sensor that detects a wide range of microbial- and host-derived signals. Inflammasome activation results in the release of the potent pro-inflammatory cytokines IL-1β and IL-18 and triggers a form of inflammatory cell death known as pyroptosis. Excessive NLRP3 activity is associated with the pathogenesis of a wide range...

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PMID: 32745339
DOI: 10.1002/jlb.3mr0720-513r

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