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Article

Mast Cells Are a Reservoir of NLRP1 in Human Skin.

International journal of molecular sciences - 23 Apr 2026

Dobre Alexandra, Fertig Tudor Emanuel, Niculae Andrei Marian, Cohn Adelina Maria, Curici Antoanela, Andrei Razvan Theodor, Marta Daciana Silvia, Peteu Victor Eduard, Popescu Roua Gabriela, Marinescu George Catalin, Turcu Gabriela, Forsea Ana Maria, Ion Daniela Adriana, Gherghiceanu Mihaela, Nedelcu Roxana Ioana

Abstract excerpt

NLRP1 is an inflammasome sensor protein expressed in barrier tissues of humans. Its activation in response to microbes or cellular stress triggers a cascade of molecular events, leading up to IL1β-driven inflammation and pyroptosis. Rare germline mutations of NLRP1 cause its persistent activation, resulting in autoinflammatory syndromes. Multiple self-healing palmoplantar carcinoma (MSPC) is one such syndrome,...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-1beta

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

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Source

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Identifiers

PMID: 42123364
DOI: 10.3390/ijms27093775
PMCID: PMC13164440

Genes

NLRP1
NLRP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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