Article

In situ evidence that mast cells release mutant NLRP1 in keratoacanthomas from multiple self-healing palmoplantar carcinoma

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> NLRP1 is an inflammasome sensor protein expressed in barrier tissues of humans. Its activation in response to microbes or cellular stress triggers a cascade of molecular events, leading up to IL1β-driven inflammation and pyroptosis. Rare germline mutations of NLRP1 cause its persistent activation, resulting in autoinflammatory syndromes. Multiple self-healing palmoplantar carcinoma (MSPC) is one...

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Literature Corpus work: bec91c5d-f421-59cf-adc6-3bfe6c1cedfe
DOI: 10.1101/2025.09.12.675637

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