Article

The G-protein coupled receptor GPR34 promotes the homeostatic state of microglia and restrains the disease-associated microglial response in an AD model

2025-12-01

Abstract excerpt

Expression of the G protein coupled receptor GPR34 is highly enriched in microglia and has been reported to be downregulated in several brain disease contexts, including Alzheimers disease (AD) and multiple sclerosis (MS). GPR34 function is poorly understood, as is its role in regulation of microglial states. Using RNA-sequencing, we find that microglia from Gpr34 knockout (KO) mouse brains exhibited a transcript...

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Literature Corpus work: e16eeb9a-3291-5062-8d83-0d016836f04d
DOI: 10.1101/2025.11.26.690816

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