Age-dependent Microglial Disease Phenotype Results in Functional Decline in Gut Macrophages

Abstract excerpt

Background and Aims Muscularis macrophages (MMs) are tissue-resident macrophages in the gut muscularis externa which play a supportive role to the enteric nervous system. We have previously shown that age-dependent MM alterations drive low-grade enteric nervous system inflammation, resulting in neuronal loss and disruption of gut motility. The current studies were designed to identify the MM genetic signature...

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