Article

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s disease

2024-10-18

Abstract excerpt

Germline genetic architecture of Alzheimer’s disease (AD) indicates microglial mechanisms of disease susceptibility and outcomes. However, the mechanisms that enable microglia to mediate protective responses to AD pathology remain elusive. Adgrg1 is specifically expressed in yolk-sac-derived microglia. This study reveals the role of yolk-sac-derived microglia in AD pathology, highlighting the function of ADGRG1 i...

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Literature Corpus work: 8b9d2d71-0d19-53e4-8869-6994c751180f
DOI: 10.1101/2024.10.15.618329

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