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Article

GPCRomics of Homeostatic and Disease-Associated Human Microglia

14 May 2021

Abstract excerpt

G-protein-coupled receptors (GPCRs) are critical sensors affecting the state of eukaryotic cells. To get systematic insight into the GPCRome of microglia, we analyzed publicly available RNA-sequencing data of bulk and single cells obtained from human and mouse brains. We identified 17 rhodopsin and adhesion family GPCRs robustly expressed in microglia from human brains, including the homeostasis-associated genes...

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PMID: 34054860
DOI: 10.3389/fimmu.2021.674189

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