Back to search

Article

Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II chemoimmunotherapy trial

2023-05-31

Abstract excerpt

<title>Abstract</title> <p>Adding anti-PD1 antibodies to 5-FU/platinum chemotherapy improves survival in a subset of advanced gastroesophageal adenocarcinoma (GEA) patients. Beyond PD-L1 expression and mismatch repair status we have limited insight into molecular predictors of response, or the relative contribution of PD-1 blockade. We conducted an investigator sponsored phase II trial (n = 47) sequentially addin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5ba873df-2df4-5099-b641-335b71e26e42
DOI
10.21203/rs.3.rs-2793348/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor immune microenvironment in advanced gastric cancer: A phase II chemoimmunotherapy trialDOI 10.21203/rs.3.rs-2793348/v1
Sequential pembrolizumab cooperates with platinum/5FU to remodel the tumor microenvironment in advanced gastric cancer: a phase II chemoimmunotherapy trialSemantic proximity
Single-cell profiling of gastric cancer ascites reveals immunosuppressive remodeling and an epithelial-immune dual phenotype signature predictive for PD-1 immunotherapy responsesSemantic proximity
Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity
Comprehensive immunophenotyping of gastric adenocarcinoma identifies an inflamed class of tumors amenable to immunotherapiesSemantic proximity
Mass cytometry uncovers distinct blood myeloid phenotypes linked to clinical responses during gastric cancer chemoimmunotherapy.Semantic proximity
Conventional therapy induces tumor immunoediting and modulates the immune contexture in colorectal cancerSemantic proximity
Immunogenomic profile of colorectal cancer response to immune checkpoint blockadeSemantic proximity
Re-clustering and profiling of digestive system tumors according to microenvironment componentsSemantic proximity
Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy.Semantic proximity
Single-cell RNA sequencing revealed heterogeneity of the immune microenvironment in gastric cancerSemantic proximity
Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancerSemantic proximity
Mutations of PI3K-AKT-mTOR Pathway as Predictors for Immune Cell Infiltration and Immunotherapy Efficacy in dMMR/MSI-H Gastric AdenocarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.