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Multi-omics sequencing of gastroesophageal junction adenocarcinoma reveals prognosis-relevant key factors and a novel immunogenomic classification.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 May 2025

Ma Zhao, Li Mengting, Li Fuqiang, Wu Kui, Wu Xianxian, Luo Tian, Gao Na, Luo Huijuan, Sui Zhilin, Yu Zhentao, Jiang Hongjing, Shang Xiaobin, Chen Chuangui, Yue Jie, Meng Fianbiao, Duan Xiaofeng, Xu Bo

Abstract excerpt

BACKGROUND: Gastroesophageal junction adenocarcinoma (GEJAC) exhibits distinct molecular characteristics due to its unique anatomical location. We sought to investigate effective and reliable molecular classification of GEJAC to guide personalized treatment. METHODS: We analyzed the whole genomic, transcriptomic, T-cell receptor repertoires, and immunohistochemical data in 92 GEJAC patients and delineated the...

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PMID: 39883307
DOI: 10.1007/s10120-025-01585-y

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