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Article

Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma

3 Apr 2024

Abstract excerpt

ABSTRACT Esophageal squamous cell carcinoma (ESCC) is a poor-prognostic cancer type with extensive intra- and inter-patient heterogeneity in both genomic variations and tumor microenvironment (TME). However, the patterns and drivers of spatial genomic and microenvironmental heterogeneity of ESCC remain largely unknown. Here, we generated a spatial multi-omic atlas by whole-exome, transcriptome, and methylome...

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PMID: 38803565
DOI: 10.1093/nsr/nwae150

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