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Article

KIF18A Inhibition as a Therapeutic Strategy in Cancers with Rb Pathway Inactivation

2026-04-20

Abstract excerpt

KIF18A inhibition has emerged as a therapeutic strategy for chromosomally unstable cancers, but clinical development is limited by the absence of a deployable predictive biomarker. Here we identify strong, diffuse p16INK4a expression, a well-established surrogate marker of Rb-pathway inactivation, as a predictive biomarker of response to KIF18A inhibition, and show that Rb-pathway inactivation marks a biologically...

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Literature Corpus work
6b66c96b-87c2-59e0-b429-3907ffe4b16a
DOI
10.64898/2026.04.14.718587
Open publication

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KIF18A Inhibition as a Therapeutic Strategy in Cancers with Rb Pathway InactivationDOI 10.64898/2026.04.14.718587
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