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GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

1 Aug 2024

Abstract excerpt

Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity. Indeed, in pre-clinical models, inhibiting the G2/M checkpoint kinase WEE1 shows promise in inhibiting SCLC growth. However, toxicity and acquired resistance limit the clinical...

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PMID: 39120974
DOI: 10.1016/j.celrep.2024.114606

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