Article

Protein sequencing with single amino acid resolution discerns peptides that discriminate tropomyosin proteoforms

2024-11-06

Abstract excerpt

Protein variants of the same gene—proteoforms—can have high molecular similarity yet exhibit different biological functions. Thus, identifying unique peptides that unambiguously map to proteoforms can provide crucial biological insights. In humans, four human tropomyosin (TPM) genes produce similar proteoforms that can be challenging to distinguish with standard proteomics tools. For example, TPM1 and TPM2 share 8...

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Literature Corpus work: e14d9130-bad2-5fe8-b688-70ff465ed1b7
DOI: 10.1101/2024.11.04.621980

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