timsTOF mass spectrometry-based immunopeptidomics refines tumor antigen identification

Abstract excerpt

<title>Abstract</title> <p>T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics represents the only unbiased method for the direct identification and characterization of naturally presented tumor-associated peptides, a key prerequisite for the development of T cell-based immunotherapies. Th...

Topics

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• Advanced Proteomics Techniques and Applications
• Colorectal Neoplasms
• Histocompatibility Antigens Class I
• Immunotherapy and Immune Responses
• Mass Spectrometry
• Mutation
• Peptidase Inhibition and Analysis
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

8f55b99c-aed1-555a-a807-cdeaceea10f7

DOI

10.21203/rs.3.rs-2402111/v1