Article

Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6

2025-02-08

Abstract excerpt

The vast complexity of the proteome currently overwhelms any single analytical technology in capturing the full spectrum of proteoform diversity. In this study, we evaluated the complementarity of two cutting-edge proteomic technologies—single-molecule protein sequencing and individual ion mass spectrometry—for analyzing recombinant human IL-6 (rhIL-6) at the amino acid, peptide, and intact proteoform levels. For...

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Literature Corpus work: 2089c1bd-bb60-58ce-9cd3-0b354a9e0b4e
DOI: 10.1101/2025.02.07.637157

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