Article

Deep thermal proteome profiling for detection of proteoforms and drug sensitivity biomarkers

2022-06-10

Abstract excerpt

The complexity of the functional proteome extends significantly beyond the protein coding genome resulting in millions of proteoforms. Investigation of proteoforms and their functional roles is important to understand cellular physiology and its deregulation in diseases, but challenging to perform systematically. Here, we apply thermal proteome profiling with deep peptide coverage to detect functional proteoforms...

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Literature Corpus work: edef643d-83d6-5505-bd1c-04d56375c142
DOI: 10.1101/2022.06.10.495491

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