Article

Detecting Amino Acid Variants Using Next-Generation Protein Sequencing (NGPS)

2024-12-20

Abstract excerpt

Next-Generation Protein Sequencing ™ (NGPS ™ ) is a single-molecule approach for characterizing protein variants, offering detailed insight into proteoforms and amino acid substitutions not easily discerned by mass spectrometry. The novel data type produced by NGPS, which is based on binding of N-terminal amino acids by fluorescently tagged recognizer proteins, requires the development of new data analysis metho...

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Literature Corpus work: 4ebe8b0f-e3f3-59a7-aa3c-abc322174612
DOI: 10.1101/2024.12.17.629036

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