Article
Direct Imaging and Identification of Proteoforms up to 70 kDa from Human Tissue
2021-12-07
Abstract excerpt
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification by 4-fold compared to reported methods, and reveals tissue localization of proteoforms at <80 μm spatial resolution. PiMS advances proteoform imaging by combining amb...
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Identifiers and source
- Literature Corpus work
- ec5dfccf-631d-596b-b1f4-88a7613843f5
- DOI
- 10.1101/2021.12.07.471638