Discovery and Targeting of a Cryptic Human Proteome

Abstract excerpt

First-in-class therapeutics require first-in-class biology. Yet despite decades of genomic and proteomic cataloging, vast regions of the human transcriptome remain dark and their encoded proteins invisible. Here we present RyboCypher™, an integrated RNA-sequencing and AI-assisted proteogenomics platform that systematically maps the RyboCypher-derived “dark” transcriptome to unannotated peptides, predicting and emp...

Topics

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• Immunotherapy and Immune Responses
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• Ubiquitin and proteasome pathways
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

ea79e91a-37f9-51f5-82d3-17a948ba1521

DOI

10.64898/2026.08.05.743124