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High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors

2020-06-02

Abstract excerpt

Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels may reveal therapeutic insights critical to combating disease. Existing discovery and targeted mass spectrometry-based methods used to monitor pTyr networks involve a tradeoff between broad coverage of the pTyr network, reproducibility in target identification...

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Literature Corpus work
0850cfb9-1abb-558c-afb8-46ec6150b503
DOI
10.1101/2020.06.01.127787
Open publication

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High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumorsDOI 10.1101/2020.06.01.127787
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