Article

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

2022-11-03

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. <italic>TP53</italic> loss of function (LOF) mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous LOF mutations in <italic>TP53</italic> and activation of c-MET occur in ~ 20% of human HCCs, and these patients show a poor prognosis. Importantly, we...

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Literature Corpus work: e0fae5dc-790d-5c7f-8ca7-37e8a1978027
DOI: 10.21203/rs.3.rs-2176178/v1

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