Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐catenin

21 Apr 2016

Abstract excerpt

Hepatocellular cancer (HCC) remains a significant therapeutic challenge due to its poorly understood molecular basis. In the current study, we investigated two independent cohorts of 249 and 194 HCC cases for any combinatorial molecular aberrations. Specifically we assessed for simultaneous HMET expression or hMet activation and catenin β1 gene (CTNNB1) mutations to address any concomitant Met and Wnt signaling....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatocellular Carcinoma Treatment and Prognosis
Share to Liver physiology and pathology
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27097116
DOI: 10.1002/hep.28601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐cateninPMID 27097116Read ↗

Targeting β‐catenin in hepatocellular cancers induced by coexpression of mutant β‐catenin and K‐Ras in miceSemantic proximity Read ↗

The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model.Semantic proximity Read ↗

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinomaSemantic proximity Read ↗

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in miceSemantic proximity Read ↗

Human-correlated genetic HCC models identify combination therapy for precision medicineSemantic proximity Read ↗

Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathwaysSemantic proximity Read ↗

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/TazSemantic proximity Read ↗

Distinct pathways of genomic progression to benign and malignant tumors of the liver.Semantic proximity Read ↗

Integrative genomic analysis of mouse and human hepatocellular carcinomaSemantic proximity Read ↗

Exploring the Impact of the β-Catenin Mutations in Hepatocellular Carcinoma: An In-Depth Review.Semantic proximity Read ↗

Human-correlated genetic models identify precision therapy for liver cancer.Semantic proximity Read ↗

β‐catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β‐catenin and METSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.