Article
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis.
Cell death & disease - 27 Jul 2023
Zhou Yi, Cui Guofei, Xu Hongwei, Chun Joanne, Yang Doris, Zhang Zheng, Yang Lihui, Wang Jingxiao, Wan Meijuan, Calvisi Diego F, Lin Shumei, Chen Xin, Wang Haichuan
Abstract excerpt
Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor prognosis. Importantly, we found that concomitant deletion of Trp53 and overexpression of c-MET (c-MET/sgp53) in...
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