Article

MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities

2022-07-21

Abstract excerpt

<title>Abstract</title> <p>Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually act as drivers of liver cancer initiation and progression. However, their concomitant alteration in HCC has not been explored, nor functionally documented. Here, we analysed databases of five independ...

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Literature Corpus work: ad2e843e-960a-56fa-ab3b-2c9966b0d8fe
DOI: 10.21203/rs.3.rs-1787765/v1

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