Construction and application of CRISPR-mediated TBCK-Knockout system in multiple human and mouse cell models

Abstract excerpt

<h4>Background: </h4> Mutations in TBCK can generate truncated TBCK protein aggregates that abolish the normal function of the gene. Alterations in TBCK function have been implicated in developmental and neurogenetic disorders, as well as the progression of certain forms of cancer. Despite TBCK&#039;s involvement in various human diseases, the underlying mechanism for cancer pathogenesis remains poorly understood....

Topics

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• Benzamides
• Cancer Mechanisms and Therapy
• CRISPR and Genetic Engineering
• False Positive Reactions
• Gene Transfer Techniques
• Indazoles
• Protein Degradation and Inhibitors
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

f632429b-fd4a-5223-8605-d3c428e50daf

DOI

10.20944/preprints202308.0943.v2