Article
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk.
Hepatology (Baltimore, Md.) - 1 Sept 2023
Lam Yin Kau, Yu Jianqing, Huang Hao, Ding Xiaofan, Wong Alissa M, Leung Howard H, Chan Anthony W, Ng Kelvin K, Xu Mingjing, Wang Xin, Wong Nathalie
Abstract excerpt
BACKGROUND AND AIMS: Major genomic drivers of hepatocellular carcinoma (HCC) are nowadays well recognized, although models to establish their roles in human HCC initiation remain scarce. Here, we used human liver organoids in experimental systems to mimic the early stages of human liver carcinogenesis from the genetic lesions of TP53 loss and L3 loop R249S mutation. In addition, chromatin immunoprecipitation...
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