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Article

Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish.

Journal of experimental & clinical cancer research : CR - 20 Aug 2021

Luo Juanjuan, Lu Chunjiao, Feng Meilan, Dai Lu, Wang Maya, Qiu Yang, Zheng Huilu, Liu Yao, Li Li, Tang Bo, Xu Chuan, Wang Yajun, Yang Xiaojun

Abstract excerpt

BACKGROUND: Liver cancer, mainly hepatocellular carcinoma, is one of the deadliest cancers worldwide and has a poor prognosis due to insufficient understanding of hepatocarcinogenesis. Previous studies have revealed that the mutations in PTEN and TP53 are the two most common genetic events in hepatocarcinogenesis. Here, we illustrated the crosstalk between aberrant Pten and Tp53 pathways during...

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Identifiers

PMID: 34416907
DOI: 10.1186/s13046-021-02061-y
PMCID: PMC8377946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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