Article

Single cell transcriptional evolution of myeloid leukaemia of Down syndrome

2025-04-03

Abstract excerpt

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukaemia (ML-DS). Unusually for a childhood leukaemia, ML-DS arises from a preleukaemic state, termed transient abnormal myelopoiesis (TAM), via a conserved sequence of mutations. Here, we examined the relationship between the genetic and transcriptional evolution of ML-DS from natural variation; a rich collection of primary patient...

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Literature Corpus work: e0f84e36-4e17-53bf-ae0a-630219d7797d
DOI: 10.1101/2025.04.01.646181

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