Article

The natural history of transient abnormal myelopoiesis in neonates and children with Down syndrome

2016-01-01

Abstract excerpt

Children with Down syndrome (DS) have a markedly increased risk of acute myeloid leukaemia (ML-DS) during the first 5 years of life compared to children without DS. Many children with ML-DS have a preceding history of a neonatal pre-leukaemic disorder known as Transient Abnormal Myelopoiesis (TAM). Both TAM and ML-DS harbour the same acquired N-terminal GATA1 mutation(s) indicating they are clonally-linked conditi...

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Literature Corpus work: 49aaf9fd-6f49-5ee9-b9c2-8444e8eeff81
DOI: 10.25560/33794

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