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Article

Clinical and biological aspects of myeloid leukemia in Down syndrome.

Leukemia - 1 Dec 2021

Boucher Austin C, Caldwell Kenneth J, Crispino John D, Flerlage Jamie E

Abstract excerpt

Children with Down syndrome are at an elevated risk of leukemia, especially myeloid leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal myelopoiesis (TAM), which is self-limited expansion of fetal liver-derived megakaryocyte progenitors. An array of international studies has led to consensus in treating ML-DS with reduced-intensity chemotherapy, leading to excellent outcomes. In...

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Identifiers

PMID: 34518645
DOI: 10.1038/s41375-021-01414-y
PMCID: PMC8639661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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