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Article

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.

British journal of haematology - 1 Oct 2009

Roy Anindita, Roberts Irene, Norton Alice, Vyas Paresh

Abstract excerpt

Children with Down syndrome (DS) have a marked increase in susceptibility to Acute Megakaryoblastic Leukaemia (DS-AMKL) and the closely linked neonatal preleukaemic syndrome, Transient Myeloproliferative Disorder (DS-TMD). The distinct stages of DS-TMD and DS-AMKL provide an excellent tractable model to study leukaemogenesis. This review focuses on recent studies describing clinical, haematological and biological...

Topics

Cell Transformation, Neoplastic
Down Syndrome
GATA1 Transcription Factor
Humans
Leukemia, Megakaryoblastic, Acute
Models, Genetic
Mutation
Myeloproliferative Disorders
Neoplasm Proteins
Preleukemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19594743
DOI: 10.1111/j.1365-2141.2009.07789.x

Genes

GATA1

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