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Down syndrome-associated leukaemias: current evidence and challenges

1 Jan 2024

Abstract excerpt

Children with Down syndrome (DS) are at increased risk of developing haematological malignancies, in particular acute megakaryoblastic leukaemia and acute lymphoblastic leukaemia. The microenvironment established by abnormal haematopoiesis driven by trisomy 21 is compounded by additional genetic and epigenetic changes that can drive leukaemogenesis in patients with DS. GATA-binding protein 1 ( GATA1) somatic...

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PMID: 39050114
DOI: 10.1177/20406207241257901

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