Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of myeloid leukemia in children with Down syndrome.

International journal of hematology - 1 Apr 2016

Saida Satoshi

Abstract excerpt

Children with Down syndrome (DS) have a markedly increased risk of leukemia. They are at particular risk of acute megakaryoblastic leukemia, known as myeloid leukemia associated with DS (ML-DS), the development of which is closely linked to a preceding temporary form of neonatal leukemia called transient abnormal myelopoiesis (TAM). Findings from recent clinical and laboratory studies suggest that constitutional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Down Syndrome
Share to GATA1 Transcription Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GATA1 gene

Share to Hematopoiesis

Share to Leukemia, Myeloid

Share to Mutation

Source

Identifiers

PMID: 26910243
DOI: 10.1007/s12185-016-1959-5

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of myeloid leukemia in children with Down syndrome.PMID 26910243Read ↗

Transient Abnormal Myelopoiesis and AML in Down Syndrome: an UpdateSemantic proximity Read ↗

Clinical and biological aspects of myeloid leukemia in Down syndrome.Semantic proximity Read ↗

Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down SyndromeSemantic proximity Read ↗

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis.Semantic proximity Read ↗

Down syndrome and leukemia: insights into leukemogenesis and translational targets.Semantic proximity Read ↗

Recent advances in the understanding of transient abnormal myelopoiesis in Down syndromeSemantic proximity Read ↗

GATA1 and cooperating mutations in myeloid leukaemia of Down syndrome.Semantic proximity Read ↗

Single cell transcriptional evolution of myeloid leukemia of Down syndrome.Semantic proximity Read ↗

Myeloid Leukemia in Down SyndromeSemantic proximity Read ↗

Single cell transcriptional evolution of myeloid leukaemia of Down syndromeSemantic proximity Read ↗

The natural history of transient abnormal myelopoiesis in neonates and children with Down syndromeSemantic proximity Read ↗

Down syndrome-associated leukaemias: current evidence and challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.