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Down syndrome and leukemia: insights into leukemogenesis and translational targets.

1 Apr 2015

Abstract excerpt

Children with Down syndrome (DS) have a significantly increased risk of childhood leukemia, in particular acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (DS-ALL). A pre-leukemia, called transient myeloproliferative disorder (TMD), characterised by a GATA binding protein 1 (GATA1) mutation, affects up to 30% of newborns with DS. In most cases, the pre-leukemia regresses spontaneously,...

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PMID: 26835364
DOI: 10.3978/j.issn.2224-4336.2015.03.03

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