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Article

GATA1 and cooperating mutations in myeloid leukaemia of Down syndrome.

IUBMB life - 1 Jan 2020

Garnett Catherine, Cruz Hernandez David, Vyas Paresh

Abstract excerpt

Myeloid leukaemia of Down syndrome (ML-DS) is an acute megakaryoblastic/erythroid leukaemia uniquely found in children with Down syndrome (constitutive trisomy 21). It has a unique clinical course, being preceded by a pre-leukaemic condition known as transient abnormal myelopoiesis (TAM), and provides an excellent model to study multistep leukaemogenesis. Both TAM and ML-DS blasts carry acquired N-terminal...

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Identifiers

PMID: 31769932
DOI: 10.1002/iub.2197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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