Article

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.

2023-09-25

Abstract excerpt

The molecular basis of Down syndrome (DS) predisposition to leukemia is not fully understood but involves various factors such as chromosomal abnormalities, oncogenic mutations, epigenetic alterations, and changes in selection dynamics. Myeloid leukemia associated with DS (ML-DS) is preceded by a preleukemic phase called transient abnormal myelopoiesis driven by GATA1 gene mutations and progresses to ML-DS through...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b257d74-369c-5929-8f3e-1bedfc2c6c81
DOI: 10.20944/preprints202309.1589.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.DOI 10.20944/preprints202309.1589.v1Read

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read

Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.Semantic proximity Read

Single cell transcriptomics reveals tumor heterogeneity in myeloid leukemia associated with Down syndromeSemantic proximity Read

Down syndrome and leukemia: An insight into the disease biology and current treatment options.Semantic proximity Read

Clinical and biological aspects of myeloid leukemia in Down syndrome.Semantic proximity Read

Down syndrome and leukemia: insights into leukemogenesis and translational targets.Semantic proximity Read

Myeloid Leukemia in Down SyndromeSemantic proximity Read

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations.Semantic proximity Read

Down syndrome-associated leukaemias: current evidence and challengesSemantic proximity Read

Advances in molecular characterization of myeloid proliferations associated with Down syndromeSemantic proximity Read

Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.Semantic proximity Read

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles.Semantic proximity Read