Single cell transcriptional evolution of myeloid leukemia of Down syndrome.

doi:10.1038/s41467-026-71707-2

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Article

Single cell transcriptional evolution of myeloid leukemia of Down syndrome.

Nature communications - 23 Apr 2026

Trinh Mi K, Schuschel Konstantin, Issa Hasan, Thomas Rebecca, Parks Conor, Oszlanczi Agnes, Ogbonnah Toochi, Zhou Di, Mamanova Lira, Prigmore Elena, Robertson Emilia R, Hodder Angus, Wenger Anna, Anderson Nathaniel D, Whitfield Holly J, Treger Taryn D, Gonçalves-Dias José, Straathof Karin, O'Connor David, Young Matthew D, Jardine Laura, Adams Stuart, Klusmann Jan-Henning, Bartram Jack, Behjati Sam

Abstract excerpt

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukaemia (ML-DS). Unusually for a childhood leukaemia, ML-DS arises from a preleukaemic state, termed transient abnormal myelopoiesis (TAM), via a conserved sequence of mutations. Here, we examine the relationship between the genetic and transcriptional evolution of ML-DS from natural variation; a rich collection of primary patient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42026063
DOI: 10.1038/s41467-026-71707-2
PMCID: PMC13106683

Genes

GATA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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