Article

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

2023-08-14

Abstract excerpt

Lung pathogenic T helper type 2 (pTh2) cells are important drivers of allergic asthma, but fundamental questions remain regarding their regulation and heterogeneity. The differentiation and effector functions of immune cells are tightly regulated by epigenetic processes. Histone deacetylase 1 (HDAC1) is an important epigenetic regulator of T cells, however, its role in pTh2 cells is yet to be determined. Here we i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65f73879-e17a-50d1-9199-3d3bb0e63785
DOI: 10.1101/2023.08.10.552772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthmaDOI 10.1101/2023.08.10.552772Read

Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthmaSemantic proximity Read

Th2 Cells in Health and DiseaseSemantic proximity Read

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory statesSemantic proximity Read

Single-Cell Analysis: A Method for In-Depth Phenotyping of Cells Involved in Asthma.Semantic proximity Read

Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway diseaseSemantic proximity Read

Epigenetic regulation of T‐helper cell differentiation, memory, and plasticity in allergic asthmaSemantic proximity Read

A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.Semantic proximity Read

Characterizing cellular heterogeneity in fibrotic hypersensitivity pneumonitis by single-cell transcriptional analysisSemantic proximity Read

Single-cell Analysis of TFH Cell Subsets in Allergic Rhinitis: Discovery of the GZMK+ TFH Cell SubsetSemantic proximity Read

Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory DiseaseSemantic proximity Read

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.Semantic proximity Read

Allergen-responsive T helper type 2 cells revealed by high-dimensional profiling in allergen challenged human airwaysSemantic proximity Read