Article

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

2025-02-09

Abstract excerpt

Rheumatoid arthritis (RA) is a systemic autoimmune disease arising from loss of tolerance and autoantibody development in at-risk individuals. Targeted therapies yield variable responses and current preventive strategies delay but do not stop disease onset. We propose that a set of transcription factors (TFs) and their downstream pathways regulate inflammatory cell communication networks in at-risk populations and...

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Literature Corpus work: 35ed0a0d-dab9-526d-8b96-f858d3e7d4ea
DOI: 10.1101/2025.02.08.619913

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