Article
Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling
2023-09-28
Abstract excerpt
<h4>ABSTRACT</h4> Unveiling the complete proteome of viruses is crucial to our understanding of the viral life cycle and interaction with the host. We developed Massively Parallel Ribosome Profiling (MPRP) to experimentally determine open reading frames (ORFs) in 20,170 designed oligonucleotides across 679 human-associated viral genomes. We identified 5,381 ORFs, including 4,208 non-canonical ORFs, and show succe...
Topics
Open a Topic to create a Post that cites this publication.
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Viral-associated cancers and disorders
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
Identifiers and source
- Literature Corpus work
- e129c509-7507-5894-9bd5-3e38a00ba2b8
- DOI
- 10.1101/2023.09.26.559641