Article

Poor codon optimality as a signal to degrade transcripts with frameshifts

2018-06-13

Abstract excerpt

Living organisms are error-prone. Every second a single human cell produces over 100 transcripts with a substitution, frameshift or splicing error. Multiple mRNA quality control pathways exist to degrade these transcripts. Many of these pathways involve co-translational regulation of mRNA stability, such as nonsense mediated decay (NMD) and reduced stability of transcripts with suboptimal codon usage. Recent work...

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Identifiers and source

Literature Corpus work: 48ec03ca-10dc-5ae6-8bca-3626eda4866b
DOI: 10.1101/345595

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