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Article

Metabolic enzyme polymorphisms and susceptibility to acute leukemia in adults.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2002

Morgan Gareth J, Smith Martyn T

Abstract excerpt

Genetic approaches to understanding the etiology of the acute leukemias are beginning to deliver meaningful insights. Polymorphic variants in xenobiotic metabolizer loci were a natural starting point to study the relevance of these changes. The finding that glutathione S-transferase (GST) T1 null variants increase leukemia risk has implicated oxidative stress in hematopoietic stem cells as an important...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12083944
DOI: 10.2165/00129785-200202020-00002

Genes

GSTP1
MPO
MTHFR
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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