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Article

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Current drug targets - 1 Jan 2016

Pey Angel L, Megarity Clare F, Medina-Carmona Encarnación, Timson David J

Abstract excerpt

NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. As a non-enzymatic function, it is involved in the stabilization of several tumour suppressors such as p53, p33 and p73&#945;. NQO1 is overexpressed in several types of tumours, and two common polymorphisms are associated with increased cancer risk, making...

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Source

Identifiers

PMID: 26721407
DOI: 10.2174/1389450117666160101121610

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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