Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

doi:10.2174/1389450117666160101121610

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Article

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Current drug targets - 1 Jan 2016

Pey Angel L, Megarity Clare F, Medina-Carmona Encarnación, Timson David J

Abstract excerpt

NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. As a non-enzymatic function, it is involved in the stabilization of several tumour suppressors such as p53, p33 and p73&#945;. NQO1 is overex...

Topics

Animals
Antineoplastic Agents
Antioxidants
Drug Design
Genetic Predisposition to Disease
Humans
Molecular Targeted Therapy
NAD(P)H Dehydrogenase (Quinone)
Neoplasms
Polymorphism, Genetic

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