Article
NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.
International journal of oncology - 1 Oct 2004
Basu Saurajyoti, Brown John E, Flannigan G Michael, Gill Jason H, Loadman Paul M, Martin Sandie W, Naylor Brian, Puri Rajiv, Scally Andrew J, Seargent Jill M, Shah Tariq, Phillips Roger M
Abstract excerpt
NAD(P)H:Quinone oxidoreductase-1 (NQO1) has been implicated in the bioreductive activation of the clinically active anticancer drug Mitomycin C (MMC) and a polymorphic variant of NQO1 which lacks functional enzyme activity (NQO1*2) has been linked with poor survival in patients treated with MMC. The relationship between NQO1 activity and cellular response to MMC is however controversial and the aim of this study...
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