Article
Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.
International journal of oncology - 1 Apr 2004
Phillips Roger M, Basu Saurajyoti, Brown John E, Flannigan G Michael, Loadman Paul M, Martin Sandie W, Naylor Brian, Puri Rajiv, Shah Tariq
Abstract excerpt
NQO1 is a cytosolic flavoprotein that plays a dual role in the detoxification of potentially carcinogenic compounds and the bioreductive activation of quinone based anticancer drugs. Two polymorphic variants of NQO1 exist (NQO1*2 and NQO1*3) which cause significant phenotypic reductions in NQO1 p...
Topics
- Carcinoma, Transitional Cell
- Formaldehyde
- Genotype
- Humans
- NAD(P)H Dehydrogenase (Quinone)
- Paraffin Embedding
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Transplantation, Heterologous
- Urinary Bladder Neoplasms