Article
Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
Lung cancer (Amsterdam, Netherlands) - 1 Nov 2001
Lewis S J, Cherry N M, Niven R M, Barber P V, Povey A C
Abstract excerpt
NAD(P)H: quinone oxidoreductase (NQO1) protects the cell against cytotoxicity by reducing the concentration of free quinone available for single electron reduction. The NQO1 gene is polymorphic and the variant protein exhibits just 2% of the enzymatic activity of the wildtype protein. In this stu...
Topics
- Aged
- Alleles
- Carcinogens
- Carcinoma, Small Cell
- Case-Control Studies
- Female
- Genotype
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Quinone Reductases
- Risk Factors