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Article

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy.

British journal of cancer - 1 Jan 1997

Kelsey K T, Ross D, Traver R D, Christiani D C, Zuo Z F, Spitz M R, Wang M, Xu X, Lee B K, Schwartz B S, Wiencke J K

Abstract excerpt

The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

Topics

Antineoplastic Agents
Ethnicity
Genetic Variation
Genotype
Humans
Polymorphism, Genetic
Quinone Reductases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9328142
DOI: 10.1038/bjc.1997.474
PMCID: PMC2228056

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9328142-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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